Screening pesticide of betacypermethrin emulsion in water. Physical stability of the formulations were checked by. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudocomponent. Pdf construction of pseudoternary phase diagram and its. Optimized microemulsion batches were selected through pseudoternary phase diagram using oleic acid, tween 80 and ipa as oil, surfactant and cosurfactant, respectively followed by stability studies and characterization. Apparently, a fixed weight or volume ratio must be selected. The influence of drug loading level on the phase diagram was also determined. The phase behavior can easily report on pseudoternary triangles. Using algebraic geometry to describe boundaries of microemulsion. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity. The microemulsion mixture containing 35% wt soybean oil, 5% wt. Construction of pseudoternary phase diagram is an important tool for.
The phases include conventional emulsion, gel viscous and transparenttranslucent microemulsion. At 45% wtwt surfactant system, microemulsions containing various ratios of water. Pseudoternary phase diagrams were used for the selection of microemulsion area. To differentiate within the twophase region and singlephase region in the ternary diagram. Various mes were selected from the pseudoternary phase diagram with 3. A pseudoternary phase diagram was constructed using water titration method. They have concluded that the interaction between water and oil domains is an important parameter affecting the stability of microemulsions roux et al. Characterization of microemulsions prepared using isopropyl. This article is from jundishapur journal of natural pharmaceutical products, volume 8. Construction of pseudoternary phase diagram is an important tool for screening of.
Fraction of a phase is determined by taking the length of the tie line to the phase boundary for the other phase, and dividing by the total length of tie line. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex. Microemulsion how to construct ternary phase diagram anyone provide step by step tutorial. Pseudoternary phase diagrams of systems containing. When the closed loop region is reached, there is an interplay of interactions which adds two 2phase regions one waterrich and one oilrich. Phase diagrams of wo microemulsion stabilised by non. The phase behavior of nonionic and anionic surfactants along with different combinations of the two were determined,different solvent,the contents of active ingredient in oil,different water hardness were investigated using pseudoternary phase diagram with betacypermethrin as the pesticide. Aminosilicone oil microemulsion,cosurfactant, phase diagram. All types of dispersions, including conventional waterinoil and oilinwater emulsions, waterinoil and oilinwater microemulsions, bicontinuous and transitional liquid crystalline structures with. In two phase region draw the tie line or isotherm 3. Microemulsions were then spontaneously prepared by mixing o. Preparation of nicotinamide microemulsions and formulation.
The influence of the drug on microemulsion area was observed. The first and second corners represented 100% of oo and w, respectively while the third corner referred to 100% of a binary mixture of smo and psmo. Preparation, optimization and characterization of microemulsions 167 5. The pseudoternary phase diagram of each system was constructed on a triangular graph to obtain microemulsion region. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of. A system consisting of water, oil, surfactant or surfactants mixture with various phases may be depicted on a phase tetrahedron whose apexes, respectively, present the pure components. The optically transparent single phase microemulsion can be formed in the region enclosed by. Design and formulation of optimized microemulsions for dermal. Research article evaluation of combination drugs before. As a consequence, phase diagrams based on two different types of small molecule surfactants tween 20 or tween 80 were constructed which define the ratios of three components in the composition of the ternary mixtures that allow the formation of oilinwater ow or waterinoil wo nano.
Transdermal delivery enhancement of carvacrol from. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram article pdf available in advanced pharmaceutical bulletin 22. Usually have elements at the corners as the constituents. Design and optimization of chlordiazepoxide solid self. The supercritical and the subcritical phase diagram each have two localized phases and two delocalized phases, separated by four critical curves meeting at a quadruple critical point. Emulsions part 3 microemulsions miniemulsions remarks to.
The microemulsion regions were defined as ow or ow type according to oil and water weight ratios. Transdermal delivery enhancement of carvacrol from origanum. Preparation and characterization of nicotinamideloaded microemulsions 35 3. Finding the amounts of phases in a two phase region. Microemulsion preparation a pseudoternary phase diagram was constructed using the aqueous phase titration method by o opti 20. Construction of pseudoternary phase diagram and its evaluation. Development and optimization of microemulsion formulation. Preparation and evaluation of tretinoin microemulsion. Lecithin is a natural amphiphilic molecule, the microemulsions of which are often employed as a transdermal delivery medium of drugs and cosmetics. An extensive investigation of the pseudoternary phase diagram of mixtures of water, isopropyl palmitate, polyoxyethylene 10 oleyl ether brij 97 c 18 e 10, and butanol is presented for two different cosurfactant concentrations, thereby varying the hydrophilicity of the amphiphile.
The stability ranges of microemulsions in systems containing soybean lecithin, alcohol, water, and. Preparation of nano and microemulsions using phase. Phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Ternary phase diagram for a ternary system chapter 10. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Isotropic mixture of oil, surfactant, cosurfactant, and drugs was formed. Pseudoternary diagram of an oilinwater propofol microemulsion of propofol oil, purified poloxamer 188 nonionic surfactant, and sodium caprylate ionic cosurfactant.
Jul 24, 2015 the use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. The wo and ow microemulsion formulations were designated as. International research journal of pharmaceutical and applied. Characterization of microemulsion structures in the pseudoternary. In this study, the effect of several shortchain alcohols on pseudoternary phase. Research article evaluation of combination drugs before the. The suitability of amounts of surfactant, cosurfactant, oily, and aqueous phases for formulation of oilinwater ow type mes was confirmed by initial. The area outside the frame indicates a turbid region with multiphase systems. Another important variable that influences the shape of the ternary phase diagram is the length of the surfactant tail l. Nmr characterization and transdermal drug delivery potential of microemulsion systems. The presence of nacl decreases the domain size of 1.
Prediction of the phase diagram with a modi ed helfrich free energy harsha mohan paroor max planck institute for polymer research mainz, germany and johannes gutenberg university, mainz, germany. Pseudoternary phase diagrams of a drug delivery system. The use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. Given the three generic binary mixtures phase diagrams, the phase diagram for the ternary abc mixture is discussed next. Effect of shortchain alcohols as cosurfactants on pseudo. The latter come in the form of theorems and conjectures. Isopleth through hypothetical ternary phase diagram at a constant.
This app, based on unpublished work by acosta, was a groundbreaking development. In this work, a pseudoternary phase diagram was designed by using soybean oil nonpolar phase, ethanol polar phase, 2butanol cosurfactant c and dbb 7104 surfactant s, and the microemulsion region was identified as a biofuel. Pseudoternary phase diagram, selfdispersible formulation, hydrophobic drug, oral. To play with that variable you can set a negative hld first and take a look at the height of the vertex of that system as you increase the length of the surfactant. Its phase diagram can be used as a guide for the selection of different microemulsion compositions for hydrothermal synthesis. Phase behavior of pseudoternary brinealkanealcohol. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex and protruding towards the wateroil axis. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion. The results showed that the area of ew was affected slightly by the nonionic surfactants and anionic.
Investigations into the formation and characterization of phospholipid microemulsions. Since the identification of microemulsions by schulman. The pseudoternary phase diagrams were constructed by drop wise addition of double distilled water to homogenous liquid mixture of oil, surfactant. Thermodynamic stability studies the thermodynamic stability of gliclazide microemulsion was evaluated using following stress tests in series. Formula optimization design of pesticide microemulsion. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. Formulation and evaluation of microemulsion based gel of.
However, it constructs a microemulsion and lamellar phase in a phase diagram without cosurfactant only at a narrow range of composition. Pdf identification of phases of various oil, surfactant. International research journal of pharmaceutical and. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. The size area of the microemulsion region of the phase diagram was found to be. Jun 01, 2011 figure 2 shows a pseudoternary phase diagram for mixtures of palm kernel oil esters, tween 80, and water at various component compositions. Pdf the purpose of this study is to give an insight into the significance of. In one app it is possible to see how the oil and water phases behave, as 2 phase or 3 phase systems.
Pseudoternary phase diagram of microemulsion composed openi. The singlephase boundary line is found on any section that. Mpde practical surfactants science prof steven abbott. In this study, the effect of several shortchain alcohols on pseudoternary phase diagrams composed of. The compositions of microemulsion were selected from the pseudoternary phase diagram which had the largest microemulsion region. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity, viscosity, differential scanning calorimetry dsc, cryofield emission scanning electron microscopy cryofesem and. The nanoemulsion region was determined by constructing a pseudoternary phase diagram using the water titration method 22. Evaluation and optimization of waterinoil microemulsion using.
The gibbs phase diagram, however, is an empirical visual observation of the state of the system and may, or may not express the true number of phases within a given composition. Note that the lower ucst may lie below the freezing point of the mixture. Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region. Effect of surfactant and surfactant blends on pseudoternary. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. Design and formulation of optimized microemulsions for. The phases include conventional emulsion, gel viscous and transparent translucent microemulsion.
Pseudoternary phase diagrams of water, oil and ssmix of. Microemulsion based formulation as drug delivery system. Pseudoternary phase diagram of microemulsion composed. Prapaporn boonme, duangkhae maneenuan and wibul wongpoowarak. Prediction of the phase diagram with a modi ed helfrich free energy harsha mohan paroor max planck institute for polymer research mainz, germany and johannes gutenberg university, mainz, germany a thesis submitted for the degree of doctor of philosophy in natural sciences may 2012. Construction of pseudoternary phase diagrams selfemulsifying drug delivery system sedds containing art and lmf was formulated by pseudoternary phase diagram using water titration method. It could be noted that the area of microemulsion region was considerably large since 1butanol acted as a cosurfactant and. To develop microemulsion based hydrogel of voriconazole was for effective treatment of skin mycosis. Cosurfactants were added to obtain nanoemulsion systems at low surfactant. Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. Effect of addition of cosurfactant on the phase behaviour of. The pseudoternary phase diagrams were constructed by drop wise addition of double distilled water to. Pseudoternary phase diagrams of water, oil and s smix of. The increased incidence of inflammatory diseases has.
For oral bioavailability enhancement of glipizide biresh k sarkar1, shiv s. First, pseudoternary phase diagrams of water or brine decanedodecanesulfonatesbutan1ol. Nov 21, 2014 phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Phase diagrams of wo microemulsion stabilised by nonionic. Throughout the article, two distinct gels, made of two different microemulsion droplets r. The fish phase diagram is obtained when an mc cut is taken across the abc triangle phase diagram. We obtain the general structure of the phase diagram, and state a number of properties that exhibit the ne structure of the phase diagram as well. A journey through the phase diagram of a pharmaceutically. The values of f a reported in table 1 clearly indicate that the systems with higher surfactant content have a much higher amphiphilic strength and thus are also expected to form more highly structured microemulsion as seen in fig. Pseudoternary phase diagrams and formulation of microemulsion of lornoxicam almond oil oil, tween 20 surfactant, dmso cosurfactant were used for formulation of microemulsion using water titration method.
The fish phase diagram is obtained when an mc cut is. The ac binary phase diagram shows three critical points. Preparation of nano and microemulsions using phase inversion. The different phases correspond to the different ways in which the copolymer can move through the microemulsion. College of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh, india. The below shows a hypothetical ternary phase diagram of a microemulsion. Pdf study of pseudoternary phase diagram behaviour and the. Pdf preparation and characterization of dexamethasone. To differentiate within the two phase region and single phase region in the ternary diagram. Characterization of microemulsion structures in the. Pseudoternary phase diagram construction and optimization quantitative ratio of components for oilinwater ow type mes was set referring to available scientific data 2, 5, 10. It is the boundary line around that singlephase region. Construction of pseudoternary phase diagram is an important tool for screening. The studies were performed employing conductometric titrations, differential scanning calorimetry.